A Modern View of the Pathogenesis of Allergy with Drug Etiology


Iskandar Mavlyanov, Abdurashid Ashirmetov, Zafar Mavlyanov, Bekhzod Abdullaev

Abstract


Nowadays many diseases are associated with a high risk of drug allergy, and this risk can vary greatly depending on the type of disease. With the progression of disease in HIV-infected patients is increased IgE and decreased the number of CD4+ T-cells. In this case violated the ratio of interferon-gamma-producing (Th1 type) clones of CD4+ T-cells and IL-4 - producing (Th2 type) clones of CD4+ T-cells. In HIV-infected patients, there is the high risk of developing allergies in the form of skin rashes and temperature, and severe skin syndromes Stevens-Jones (SJS) and toxic epidermal necrolysis (TEN) in 6%-10% of cases. CD4+ T cells secrete cytokines, for instance Interleukin (IL-5), Gransim and Eotaxin involve eosinophils to be grown and differentiated. Studies on the antigenicity of antibiotics demonstrated the potential relevance of both categories of drug allergy: hapten and p-i models. In patients with allergic reaction to piperacillin, this medication acts as the hapten, with the formation of the immunogenic conjugate piperacillin - albumin, which stimulates the drug-responsive T-cells. Immunogenetic factors have been identified as risk indicators for the development of hypersensitivity reactions to the representatives of many classes of drugs, such as Abacavir and Nevirapine, Carbamazepine and Allopurinol, etc. Thus, considering the huge genetic polymorphism in systems of drug metabolism in the body and in the systems contributing immune response to the resulting products of conjugation of hapten-protein, evident is the need to further study the role of these systems in the occurrence of adverse reactions to drug therapy, in particular, in the development of allergic complications.

Keywords


Drug, Allergy, HIV, Antibiotics, HLA system, Hypersensitivity.

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About this article

Title

A Modern View of the Pathogenesis of Allergy with Drug Etiology

Keywords

Drug, Allergy, HIV, Antibiotics, HLA system, Hypersensitivity.

DOI

10.20448/journal.504/2016.3.4/504.3.50.56

Date

2016-12-21

Additional Links

Manuscript Submission

Journal

Journal of Life Sciences Research
Vol 3, No 4 (2016) Page: 50-56

Print ISSN

2518-0126

Online ISSN

2408-9184

Statistics

158 Views | 81 Downloads

Citations

0

Authors & Affiliations

Iskandar Mavlyanov
MD, PhD of Clinic Pharmacology Department, Tashkent Medical Academy, Tashkent
Uzbekistan

Abdurashid Ashirmetov
Researcher of Scientific Research Institute of Hematology and Blood Transfusion, Ministry of Health, Tashkent
Uzbekistan

Zafar Mavlyanov
Senior research fellow of the Department of Clinical Pharmacology, Tashkent Medical Academy, Tashkent
Uzbekistan

Bekhzod Abdullaev
Scientific researcher, student of GP faculty, 4th year, Tashkent Medical Academy, Tashkent
Uzbekistan


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Journal of Life Sciences Research
Online ISSN: 2408-9184 | Print ISSN: 2518-0126
Google-based Impact Factor (2017): 1.63

 

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